Zeldox (ziprasidone)

Brand name: Zeldox®

Active ingredient: Ziprasidone

Type: Atypical antipsychotic

Available from: Upjohn Canada ULC

Form: Oral capsules

Generic: Yes — Auro‑Ziprasidone

Listed on Ontario formulary: Yes

OHIP+ coverage: Yes

What is Zeldox used for?

Used to treat schizophrenia and bipolar disorder in adults.

How should I take Zeldox?

Must be taken with food (after a full meal).
Usually taken twice daily.
Available in 20 mg, 40 mg, 60 mg, 80 mg capsules.
Typical range: 20–80 mg twice daily.

Common side effects

Fatigue/sleepiness
Nausea/upset stomach
Constipation
Dizziness
Headache
EPS

Rare but serious side effects

Agranulocytosis
Stroke
Severe allergic reaction
Sudden cardiac death
Torsades de pointes
DKA
NMS

Warnings/Precautions

Not approved for dementia‑related psychosis.
May affect heart rhythm — caution in long QT syndrome, recent MI, or severe heart failure.
Rare serious skin reactions reported in the US.

Medication interactions

Interactions may occur with:

Diphenhydramine
Lorazepam/zopiclone
Fentanyl

Avoid alcohol or illegal drugs.