Vraylar (cariprazine)

Brand name: Vraylar®

Active ingredient: Cariprazine

Type: Atypical antipsychotic

Available from: AbbVie

Form: Oral capsules (1.5–6 mg)

Generic: No

Listed on Ontario formulary: Yes
OHIP+ coverage: Yes

What is Vraylar used for?

Used for schizophrenia in adults.
Also approved for major depressive disorder and bipolar disorder.

How should I take Vraylar?

Take once daily with or without food.
Available in 1.5, 3, 4.5, 6 mg capsules.
Typical schizophrenia dose: 1.5–6 mg/day (commonly 6 mg).
Higher doses (e.g., 9 mg) were tested but showed no added benefit.

Common side effects

Weight gain
EPS
Restlessness
Headache
Insomnia
Nausea
Toothache
Constipation

Rare but serious side effects

Low white blood cells
Stroke
Severe allergic reaction
DKA
NMS
Suicidal ideation

Warnings/Precautions

Not approved for dementia‑related psychosis.

Medication interactions

Potential interactions with:

Diphenhydramine
Lorazepam/zopiclone
Fentanyl
Dopamine agonists

Avoid alcohol and illegal drugs.