Saphris (asenapine)

Brand name: Saphris®

Active ingredient: Asenapine

Type: Atypical antipsychotic

Available from: Organon Canada Inc.

Form: Sublingual tablets (5 mg, 10 mg)

Generic: No

Listed on Ontario formulary: Yes (with suggested criteria*)

OHIP+ coverage: Yes (with suggested criteria*)

*Suggested for bipolar I disorder when other agents are ineffective or not tolerated.

What is Saphris used for?

Used to treat schizophrenia in adults.
Also used for bipolar disorder.

How should I take Saphris?

Tablet dissolves under the tongue.
Do not chew, crush, or swallow whole.
Do not eat or drink for 10 minutes after taking.
Usually taken twice daily.

Available strengths: 5 mg, 10 mg

Common side effects

Drowsiness
Restlessness (akathisia)
Headache
Extrapyramidal symptoms
Nausea/upset stomach
Insomnia
Dizziness
Weight gain

Rare but serious side effects

Agranulocytosis
Stroke
Severe allergic reaction
DKA
NMS

Warnings/Precautions

Not approved for dementia‑related psychosis.

Medication interactions

Interactions may occur with:

Diphenhydramine
Lorazepam, zopiclone
Fentanyl
Fluvoxamine (may increase levels)

Avoid alcohol or illegal drugs.