Rexulti (brexiprazole)

Rexulti (brexiprazole)

Brand name: Rexulti®

Active ingredient: Brexpiprazole

Type: Atypical antipsychotic

Available from: Otsuka Pharmaceutical Co. Ltd.

Form: Oral tablets (0.25–4 mg)

Generic: No

Listed on Ontario formulary: Yes

OHIP+ coverage: Yes

What is Rexulti used for?

Treatment of schizophrenia in adults.
May also be used for depression.

How should I take Rexulti?

Take once daily, with or without food.
Available in 0.25–4 mg strengths.
Typical dose range: 2–4 mg/day.

Common side effects

• Weight gain
• High triglycerides
• EPS
• Restlessness
• Headache
• Drowsiness

Rare but serious side effects

Same as other atypicals:

• Agranulocytosis
• Stroke
• Anaphylaxis
• DKA
• NMS

Warnings/Precautions

Not approved for dementia-related psychosis.

Medication interactions

Increase levels:

• Ketoconazole
• Quinidine
• Bupropion

Decrease levels:

• Rifampin
• Carbamazepine
• John’s Wort
• Other interactions:
• Diphenhydramine
• Lorazepam/zopiclone
• Fentanyl
• Dopamine agonists